SH-4-54 CAS:1456632-40-8

SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5,respectively.SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs)and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.Moreover,in vivo,SH-4-54 exhibited blood-brain barrier permeability,potently controlled glioma tumor growth,and inhibited pSTAT3 in vivo.

msds---SH-4-54